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From DNAPrint.com: |
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LATEST PRESS RELEASE: |
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March 15, 2006
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SARASOTA, FL --
(MARKET WIRE)
-- 03/14/2006 -- DNAPrint Genomics, Inc. (OTC BB: DNAG) today
announced that research to develop commercial grade PT-401, a more powerful
form of the anemia drug Erythropoietin (EPO), is proceeding on schedule
with the manufacturing of PT-401 in mammalian cells being shown to be very
efficient. Erythropoietin (EPO) has a worldwide market exceeding $11
billion and is growing at an average annual rate of 18% for the past 5
years.
"Based on these results, research is on schedule for our first
pharmaceutical product," stated Hector J. Gomez, M.D., Ph.D., Chairman and
Chief Medical Officer of DNAPrint Genomics and the Company's DNAPrint
Pharmaceuticals subsidiary. "Tests of our Super EPO dimer in animal models
of anemia showed that it was several times more effective and longer acting
than the currently available erythropoietin."
In vitro testing in cell cultures revealed significant positive biological
activity shown by marked growth stimulation of target mammalian blood
cells, either attached to solid surfaces or growing in suspension,
according to Dr. Gomez. In addition, in vivo testing in mice demonstrated
that even with a single injection, robust stimulation of red blood cell
production was produced as assessed by an increase in the number and volume
of blood cells (hematocrit). Further analytical testing showed that the
dimer exhibits unique biochemical properties that distinguish it from
currently marketed red blood cell growth stimulating drugs.
"We are very pleased that our original plan of achieving production
efficiency with an optimal structure/activity profile has been
accomplished," Dr. Gomez stated. "The next steps are to continue our scale
up development work, and then select a qualified manufacturer to make drug
material for our preclinical studies."
DNAPrint Genomics President and Chief Executive Officer Richard Gabriel
noted that development of this novel compound is a long-term project.
"These early indicators are encouraging and we will continue to pursue
development and eventual commercialization of this exciting new drug
compound," he said.
DNAPrint Genomics obtained an exclusive worldwide license from Harvard
Medical School's Beth Israel Deaconess Medical Center (BIDMC) in February
2005 for the development of a "Super" EPO, a more potent and longer acting
form of Erythropoietin (EPO). DNAPrint Pharmaceuticals' goal is to utilize
recent genomics and chemistry advances to develop next-generation test/drug
combinations called "Theranostics," which maximizes efficacy and minimizes
side effects by tailoring and customizing medication for specific
individuals and well-defined population sectors.
In June 2005, DNAPrint selected Proteos, Inc., to handle preclinical
analysis of PT-401 and to manufacture the initial batches of the new drug.
Please see:
http://www.dnaprint.com/welcome/press/press_recent/2005/0614/
About Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center is a patient care, teaching and
research affiliate of Harvard Medical School, and ranks fourth in National
Institutes of Health funding among independent hospitals nationwide. BIDMC
is clinically affiliated with the Joslin Diabetes Center and is a research
partner of Dana-Farber/Harvard Cancer Center. BIDMC is the official
hospital of the Boston Red Sox. For more information, visit
www.bidmc.harvard.edu.
About DNAPrint Genomics, Inc.
DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based
products and services in two primary markets: biomedical and forensics.
DNAPrint Pharmaceuticals, Inc., a wholly owned subsidiary, develops
diagnostic tests and theranostic products (drug/test combinations) using
the Company's proprietary ancestry-informed genetic marker studies combined
with proprietary computational modeling technology. Computational Biology
and Pharmacogenomics services are also offered externally to
biopharmaceutical companies. The Company's first theranostic product is
PT-401, a "Super EPO" (erythropoietin) dimer protein drug for treatment of
anemia in renal dialysis patients (end stage renal disease). Preclinical
and clinical development of all the Company's drug candidates will benefit
from simulated pre-trials to design actual trials better and are targeted
to patients with genetic profiles indicating their propensity to have the
best clinical responses. DNAPrint is proud of its continued dedication to
developing and supplying new technological advances in law enforcement and
consumer ancestry heritage interests. Please refer to www.dnaprint.com for
information on law enforcement and consumer applications which include
DNAWITNESS™, RETINOME™, ANCESTRYbyDNA™ and EURO-DNA™.
DNAWitness-Y and DNAWitness-Mito are two tests offered by the Company. The
results from these tests may be used as identification tools when a DNA
sample is deteriorated or compromised or other DNA testing fails to yield
acceptable results.
Forward-Looking Statements
All statements in this press release that are not historical are
forward-looking statements. Such statements are subject to risks and
uncertainties that could cause actual results to differ materially from
those projected, including, but not limited to, uncertainties relating to
technologies, product development, manufacturing, market acceptance, cost
and pricing of DNAPrint's products, dependence on collaborations and
partners, regulatory approvals, competition, intellectual property of
others, and patent protection and litigation. DNAPrint Genomics, Inc.
expressly disclaims any obligation or undertaking, except as may be
required by applicable law or regulation to release publicly any updates or
revisions to any
forward-looking statements contained herein to reflect any change in
DNAPrint's expectations with regard thereto or any change in events,
conditions, or circumstances on which any such statements are based.
Company Contact: Richard Gabriel CEO and President 941 366-3400 or Ron Stabiner The Wall Street Group, Inc. 212-888-4848SOURCE: DNAPrint Genomics, Inc. |
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