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From DNAPrint.com: |
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LATEST PRESS RELEASE: | |||
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May 16, 2006
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DNAPrint Pharmaceutical Completes Computational Model to Guide Preclinical Development on Anemia Drug "One of the most difficult steps in any drug development
program is the
leap from animal test data to initiating human studies,"
Dr. Gomez said.
"We are experiencing how rigorous computational models can
help us to
bridge the gap with much more confidence as we determine
how data generated
from testing on laboratory mice can be applied to human
biology." DNAPrint Pharmaceuticals is working on the development of
"theranostic"
genetic test/drug combinations designed to improve a drug's
efficacy and
reduce potential side effects. PT-401 is the lead drug in
DNAPrint's
product pipeline. PT-401 is a "Super EPO," a more powerful
form of
erythropoietin, a well-known drug used for the treatment
of anemia. PT-401
is a potential competitor in the EPO market that exceeds
$11 billion and is
rapidly growing. The EPOFusion(TM) model simulates the cellular and molecular
dynamics
influenced by the administration of the erythropoietin class
of protein
drugs in anemia treatments. EPOFusion(TM) models the interaction
of PT-401
-- a novel 2-copy (dimer) form of erythropoietin -- with
the cells that
trigger the production of new red blood cells. EPOFusion(TM)
can be
manipulated to test hundreds of conditions and variables
by simulating what
occurs in the whole blood cell production process. The EPOFusion(TM)
model
has already identified important differences between PT-401
and currently
marketed drugs or drugs in development by other companies.
This type of
information may provide a competitive advantage and is critical
for
transparent regulatory filings and effective physician education
upon FDA
approval of a drug for clinical testing. "We are beginning to reap the benefits of computational
biology technology
acquired by the Company in November 2005," stated DNAPrint
President and
Chief Executive Officer Richard Gabriel. "This first generation
of
EPOFusion(TM) is designed to support the basic science studies
required for
drugs before human testing. Our Computational Biology Division
will be
advancing EPOFusion(TM) to a second generation model, using
knowledge
gained in the preclinical phase, for an expanded version
(EPOFusion(TM) II)
used to simulate clinical (human) studies." Mr. Gabriel said that EPOFusion(TM) II will model the molecular
and
cellular effects of PT-401 so that researchers can ask more
"what if"
questions about dosage levels and scheduling, as well as
the drug's
influence on varying patient factors. "The data gathered
from these
simulations help guide the design of actual clinical trials,"
he said. "We
believe that application of EPOFusion(TM) enhances the potential
for
successful trials targeted to the right patients with an
effective dosing
regimen and we anticipate that this will result in reduced
time and costs
of clinical studies." About DNAPrint Genomics, Inc. DNAPrint Genomics, Inc. (www.dnaprint.com)
is a developer of genomics-based
products and services in two primary markets: biomedical
and forensics.
DNAPrint Pharmaceuticals, Inc., a wholly owned subsidiary,
develops
diagnostic tests and theranostic products (drug/test combinations)
using
the Company's proprietary ancestry-informed genetic marker
studies combined
with proprietary computational modeling technology. Computational
Biology
and Pharmacogenomics services are also offered externally
to
biopharmaceutical companies. The Company's first theranostic
product is
PT-401, a "Super EPO" (erythropoietin) dimer protein drug
for treatment of
anemia in renal dialysis patients (with end stage renal
disease).
Preclinical and clinical development of all the Company's
drug candidates
will benefit from simulated pre-trials to design actual
trials better and
are targeted to patients with genetic profiles indicating
their propensity
to have the best clinical responses. DNAPrint is proud of
its continued
dedication to developing and supplying new technological
advances in law
enforcement and consumer ancestry heritage interests. Please
refer to
www.dnaprint.com for
information on law enforcement and consumer
applications which include DNAWITNESS(TM), RETINOME(TM),
ANCESTRYbyDNA(TM)
and EURO-DNA(TM). DNAWitness-Y and DNAWitness-Mito are two
tests offered by
the Company. The results from these tests may be used as
identification
tools when a DNA sample is deteriorated or compromised or
other DNA testing
fails to yield acceptable results. Forward-Looking Statements All statements in this press release that are not historical
are
forward-looking statements. Such statements are subject
to risks and
uncertainties that could cause actual results to differ
materially from
those projected, including, but not limited to, uncertainties
relating to
technologies, product development, manufacturing, market
acceptance, cost
and pricing of DNAPrint's products, dependence on collaborations
and
partners, regulatory approvals, competition, intellectual
property of
others, and patent protection and litigation. DNAPrint Genomics,
Inc.
expressly disclaims any obligation or undertaking, except
as may be
required by applicable law or regulation to release publicly
any updates or
revisions to any
forward-looking statements contained herein to reflect any
change in
DNAPrint's expectations with regard thereto or any change
in events,
conditions, or circumstances on which any such statements
are based. |
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