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From DNAPrint.com: |
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LATEST PRESS RELEASE: | |
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July 17, 2006
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DNAPrint Genomics, Inc. (OTCBB: DNAG) today announced it has
confirmed positive results in an animal model for anti-depressant
activity for its PT-502 lead compound being developed with the
Massachusetts College of Pharmacy and Health Sciences. "The results of the assay are encouraging and have enabled us to
select PT-502 as the lead candidate for a new anti-depressant
therapy," stated Dr. Mark Froimowitz, Research Professor of Chemistry
at the Boston College. "The test results clearly show that PT-502 is
active in a widely used animal assay for anti-depressant activity.
This approach uses the dopamine system as a means of treating
depression and is different from traditional serotonin and
norepinephrine reuptake inhibitors such as Prozac(TM)."
In October 2005, DNAPrint Genomics announced that it has licensed a
series of Ritalin(TM)-like compounds developed by Dr. Froimowitz.
Ritalin(TM) is a well-known drug used for the treatment of attention
deficit hyperactivity disorder (ADHD). These compounds have the
potential to be enhanced pharmaceuticals for the clinical treatment
of depression, drug addiction and ADHD. Dr. Froimowitz noted that anywhere from 30% or more of the patients
treated with available anti-depressants either do not respond to
treatment or have adverse side effects. "PT-502 is our new compound
designed to selectively block the reuptake of dopamine with a slow
onset, and a longer duration of action. This pharmacokinetic
profile indicates that PT-502 should have little or no abuse
potential. This offers a new model for the treatment of depression
that affects nearly 20 million people a year in the U.S. alone.
Finding a treatment that may augment or enhance the use of serotonin
and norepinephrine reuptake inhibitors could help millions of people
suffering with depression." "We are very encouraged by these preliminary results from Dr.
Froimowitz's laboratory and we will be advancing the PT-502 compound
as quickly as possible," said Hector J. Gomez, M.D., Ph.D., Chairman
and Chief Medical Officer of DNAPrint and the Company's DNAPrint
Pharmaceuticals division. "Neurological compounds such as those in
our PT-500 series are exciting additions to our growing product and
diagnostic development pipeline." Richard Gabriel, President and Chief Executive Officer of DNAPrint
Genomics, noted that the compound series that the Company licensed
from Dr. Froimowitz are focused on drug addiction, depression and
attention deficit disorder. "We believe, as do many researchers and
clinicians in the psychiatric field, that strong links may exist for
certain individuals between drug addiction, attention deficit and
depression in clinical evaluations of those individuals and it is
important to understand the neurological inter-relationships between
the three neurological disorders," he stated. "We will not only be
using our Systems Biology to understand the relationships between
these three distinct disorders but we will utilize our DNA Ancestry
Informative Marker technology to help us sort out the patient
population groups that are the most responsive to treatment using
this new model of treatment for depression. We believe this will give
us a significant advantage over existing drug therapies, especially
for the refractive patient groups that may not respond to the 'one
pill fits all' design of currently approved drugs." About DNAPrint Genomics, Inc. DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of
genomics-based products and services in two primary markets:
biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a wholly
owned subsidiary, develops diagnostic tests and theranostic products
(drug/test combinations) using the Company's proprietary
ancestry-informed genetic marker studies combined with proprietary
computational modeling technology. Computational Biology and
Pharmacogenomics services are also offered externally to
biopharmaceutical companies. The Company's first theranostic product
is PT-401, a "Super EPO" (erythropoietin) dimer protein drug for
treatment of anemia in renal dialysis patients (with end stage renal
disease). Preclinical and clinical development of all the Company's
drug candidates will benefit from simulated pre-trials to design
actual trials better and are targeted to patients with genetic
profiles indicating their propensity to have the best clinical
responses. DNAPrint is proud of its continued dedication to
developing and supplying new technological advances in law
enforcement and consumer ancestry heritage interests. Please refer to
www.dnaprint.com for information on law enforcement and consumer
applications which include DNAWitness(TM), RETINOME(TM),
AncestryByDNA(TM) and EuroDNA(TM). DNAWitness-Y and DNAWitness-Mito
are two tests offered by the Company. The results from these tests
may be used as identification tools when a DNA sample is deteriorated
or compromised or other DNA testing fails to yield acceptable
results. Forward-Looking Statements All statements in this press release that are not historical are
forward-looking statements. Such statements are subject to risks and
uncertainties that could cause actual results to differ materially
from those projected, including, but not limited to, uncertainties
relating to technologies, product development, manufacturing, market
acceptance, cost and pricing of DNAPrint's products, dependence on
collaborations and partners, regulatory approvals, competition,
intellectual property of others, and patent protection and
litigation. DNAPrint Genomics, Inc. expressly disclaims any
obligation or undertaking, except as may be required by applicable
law or regulation to release publicly any updates or revisions to any
forward-looking statements contained herein to reflect any change in
DNAPrint's expectations with regard thereto or any change in events,
conditions, or circumstances on which any such statements are based.
SOURCE: DNAPrint Genomics, Inc. |
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